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Raloxifene

Also indexed as: Evista

Illustration

Raloxifene is a type of drug called a selective oestrogen receptor modulator (SERM). It is used to prevent osteoporosis in women after menopause.

Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, a herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

Beneficial May Be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them.

Phytoestrogens
Side effect reduction/prevention

None known
Supportive interaction

None known
Reduced drug absorption/bioavailability

None known
Adverse interaction

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Herbs

Formononetin
Some chemicals called phytoestrogens, found naturally in plants, have oestrogen-like activity; and some people use these phytoestrogens from dietary sources or from supplements to prevent or treat hormone-related health problems. In test tube studies, the oestrogenic activity of one phytoestrogen, formononetin, was blocked by raloxifene.1 Further research is necessary to determine the overall effect of raloxifene on formononetin and other phytoestrogens in humans.

References

1. Ruh MF, Taylor JA, Howlett AC, Welshons WV. Failure of cannabinoid compounds to stimulate estrogen receptors. Biochem Pharmacol 1997;53:35–41.